Ketogenic - Lymphatic References
Papers investigating the use of carbohydrate restriction for Lipedema
Amato, A. C. M., & Benitti, D. A. (2021). Lipedema can be treated non-surgically: A report of 5 cases. The American Journal of Case Reports, 22, e934406-1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8667633/
Amato, A. C., Amato, L. L., Benitti, D., & Amato, J. L. (2023). Assessing the Prevalence of HLA-DQ2 and HLA-DQ8 in Lipedema Patients and the Potential Benefits of a Gluten-Free Diet. Cureus, 15(7). https://pmc.ncbi.nlm.nih.gov/articles/PMC10329849/
Amato, A. C. M., Amato, J. L. S., & Benitti, D. A. (2024). The Efficacy of Ketogenic Diets (Low Carbohydrate; High Fat) as a Potential Nutritional Intervention for Lipedema: A Systematic Review and Meta-Analysis. Nutrients, 16(19), 3276. Link to the paper is here.
Apkhanova, TV, Sergeev, VN, Krukova, MM et al. (2021). Influence of Ketogenic Diet and Nutraceutical Correction in the Complex Treatment of Lower Limbs Lipedema. Bulletin of Rehabilitation Medicine, 20(5), 26-36. Link to the paper is here.
Cannataro, R., Michelini, S., Ricolfi, L., et al. (2021). Management of Lipedema with Ketogenic Diet: 22-Month Follow-Up. Life, 11(12), 1402. https://www.mdpi.com/2075-1729/11/12/1402
Di Renzo, Laura, et al. (2023). Modified Mediterranean-Ketogenic Diet and Carboxytherapy as Personalized Therapeutic Strategies in Lipedema: A Pilot Study. Nutrients 15(16), 3654. https://www.mdpi.com/2072-6643/15/16/3654
Faerber, G. & Keith, L. (2021, December). Is Lipedema Resistant to All Diets? The Impact of a Protein-optimized Ketogenic Diet on Women with Lipedema. [Poster Presentation]. Canadian Lymphoedema Framework, Virtual Conference. Link for poster is here.
Jeziorek M, Szuba A, Kujawa K, Regulska-Ilow B. (2022). The Effect of a Low-Carbohydrate, High-Fat Diet versus Moderate-Carbohydrate and Fat Diet on Body Composition in Patients with Lipedema. Diabetes Metab Syndr Obes. 15, 2545-2561 https://doi.org/10.2147/DMSO.S377720
Jeziorek, M., Szuba, A., Sowicz, M., Adaszyńska, A., Kujawa, K., & Chachaj, A. (2023). The effect of a low-carbohydrate high-fat diet on laboratory parameters in women with lipedema in comparison to overweight/obese women. Nutrients, 15(11), 2619. https://www.mdpi.com/2072-6643/15/11/2619
Jin, Y., Benzine, R., Dunford, L., Fetzer, S., & Warrilow, M. (2022). An Investigation Into the Impact of Diet and Lifestyle on the Management of Lipoedema. Current Developments in Nutrition, 6(Supplement_1), 1064-1064. https://www.sciencedirect.com/science/article/pii/S2475299123209026
Keith, L., Seo, C. A., Rowsemitt, C., Pfeffer, M., Wahi, M., Staggs, M., ... & Carmody, M. (2021). Ketogenic diet as a potential intervention for lipedema. Medical Hypotheses, 146, 110435. Link to paper is here.
Kunzová M. (2023). Optimizing nutrition for the treatment of lipedema – new pathways to improved quality of life. ČASOPIS LÉKAŘŮ ČESKÝCH, 162, 248–250. https://pubmed.ncbi.nlm.nih.gov/38981725/
Lundanes, J., Sandnes, F., Gjeilo, K. H., Hansson, P., Salater, S., Martins, C., & Nymo, S. (2024). Effect of a low‐carbohydrate diet on pain and quality of life in female patients with lipedema: a randomized controlled trial. Obesity. https://onlinelibrary.wiley.com/doi/full/10.1002/oby.24026
Lundanes, J., Gårseth, M., Taylor, S., Crescenzi, R., Pridmore, M., Wagnild, R., ... & Nymo, S. (2024). The effect of a low-carbohydrate diet on subcutaneous adipose tissue in females with lipedema. Frontiers in Nutrition, 11, 1484612. Link for full text paper is here.
Lundanes, J., Storliløkken, G. E., Solem, M. S., Dankel, S. N., Tangvik, R. J., Ødegård, R., ... & Nymo, S. (2024). Gastrointestinal hormones and subjective ratings of appetite after low-carbohydrate vs low-fat low-energy diets in females with lipedema–a randomized controlled trial. Clinical Nutrition ESPEN. Paper is here.
Pitotti, G., Vincenti, S., Basciani, S., Michelini, S. (2024). Lipedema and Nutrition: High Fat Ketogenic Diet as Treatment of Choice. Journal of Gastroenterology & Hepatology Reports 5(2):1-9. Link is here.
Sandnes, F. H. (2022). Effect of ketosis on pain and quality of life in women with lipedema (Master's thesis, UiT Norges arktiske universitet). Link to thesis is here.
Sørlie, V., De Soysa, A. K., Hyldmo, A. A., et al. (2021). Effect of a ketogenic diet on pain and quality of life in patients with lipedema: The LIPODIET pilot study. Obesity Science & Practice. Link to paper is here.
Verde, L., Camajani, E., Annunziata, G., Sojat, A., Marina, L. V., Colao, A., ... & Barrea, L. (2023). Ketogenic Diet: A Nutritional Therapeutic Tool for Lipedema?. Current Obesity Reports, 12(4), 529-543. Link is here.
Papers investigating the use of carbohydrate restriction for Lymphedema
Bellomo, R. G., Buda, R., Porreca, A., Virgili, E., Postacchini, G., Bacci, P. A., ... & Barbato, C. (2022). Treatment of lymphedema, two methods compared: Ketogenic diet and Endospheres, Ketogenic diet and Vodder lymphatic drainage. Journal of Applied Cosmetology, 40(1), 54-68. Link to the paper is here.
Keith, L., Rowsemitt, C., & Richards, L. G. (2020). Lifestyle modification group for lymphedema and obesity results in significant health outcomes. American journal of lifestyle medicine, 14(4), 420-428. Link is here.
Keith, L. & Erkstam, R. Optimizing Lymphedema Outcomes through Lifestyle. OBM Integrative and Complementary Medicine 8(1) (2023): 1-13. https://www.lidsen.com/journals/icm/icm-08-01-016
Lodewijckx, I., Matthys, C., Verheijen, J., Verscuren, R., Devoogdt, N., Van der Schueren, B., ... & Thomis, S. (2024). Potential therapeutic effect of a ketogenic diet for the treatment of lymphoedema: Results of an exploratory study. Journal of Human Nutrition and Dietetics. Link is here.
Puchalska, P. & P. A. Crawford (2019). Ketogenic therapies for lymphedema? Nat Metab 1(7). 656–657. https://www.nature.com/articles/s42255-019-0090-3
Dietary Influences on Lymphatic System Function
Chakraborty, S., Zawieja, S., Wang, W., Zawieja, D. C., & Muthuchamy, M. (2010). Lymphatic system: a vital link between metabolic syndrome and inflammation. Annals of the New York Academy of Sciences, 1207, E94-E102. https://pmc.ncbi.nlm.nih.gov/articles/PMC2965625/
Garcia-Caballero, M., et al. (2019). Role and therapeutic potential of dietary ketone bodies in lymph vessel growth. Nat Metab 1(7): 666–675. https://www.nature.com/articles/s42255-019-0087-y
Lee, Y., Chakraborty, S., Meininger, C. J., & Muthuchamy, M. (2018). Insulin resistance disrupts cell integrity, mitochondrial function, and inflammatory signaling in lymphatic endothelium. Microcirculation, 25(7), e12492. https://pmc.ncbi.nlm.nih.gov/articles/PMC6170722/
Miura, et al. (1987). Increased lymphocyte transport by lipid absorption in rat mesenteric lymphatics. American Journal of Physiology-Gastrointestinal and Liver Physiology, 253(5), G596-G600. Abstract is here. Contact me if you would like the full paper.
Miura, et al. (1993). Increased proliferative response of lymphocytes from intestinal lymph during long chain fatty acid absorption. Immunology, 78(1), 142. https://pmc.ncbi.nlm.nih.gov/articles/PMC1421772/#supplementary-material1
Scallan, J. P., Hill, M. A., & Davis, M. J. (2015). Lymphatic vascular integrity is disrupted in type 2 diabetes due to impaired nitric oxide signalling. Cardiovascular research, 107(1), 89-97. https://pmc.ncbi.nlm.nih.gov/articles/PMC4490202/
Wong, B. W., Wang, X., Zecchin, A., Thienpont, B., Cornelissen, I., Kalucka, J., ... & Carmeliet, P. (2017). The role of fatty acid β-oxidation in lymphangiogenesis. Nature, 542(7639), 49-54. Abstract is here. Contact me for the full text of this paper.
Zawieja, S. D., Wang, W., Wu, X., Nepiyushchikh, Z. V., Zawieja, D. C., & Muthuchamy, M. (2012). Impairments in the intrinsic contractility of mesenteric collecting lymphatics in a rat model of metabolic syndrome. American Journal of Physiology-Heart and Circulatory Physiology, 302(3), H643-H653. https://journals.physiology.org/doi/full/10.1152/ajpheart.00606.2011
Please contact me if you need any help locating these papers, or if you have found a paper or publication that I have missed. Enjoy your research!
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